1. Joetham A, Schedel M, Ning F, Wang M, Takeda K, Gelfand EW. Dichotomous role of TGF-β controls inducible regulatory T-cell fate in allergic airway disease through Smad3 and TGF-β-activated kinase 1. J Allergy Clin Immunol. 2020. 145(3):933-946.e4. PMID: 31626843.
  2. Ning N, Takeda K, Schedel M, Domenico J, Joetham A, Gelfand EW. Hypoxia Enhances CD8+ Tc2 Dependent Airway Hyperresponsiveness and Inflammation Through Hypoxia Inducible Factor 1a, J Allergy Clin Immunol. 2019. 143(6):2026-2037. PMID: 30660639.
  3. Gelfand EW, Schedel M. Molecular endotypes contribute to the heterogeneity of asthma, Immunol Allergy Clin North Am. 2018. 38(4):655-665. PMID: 28658551
  4. Landgraf-Rauf K, Böck A, Raedler D, Klucker E, Vogelsang V, Schmidt S, Kunze S, Weissenbacher C, Graessel A, Schmidt-Weber C, von Mutius E, Schedel M, Schaub B. IRF-1 SNPs influence the risk for childhood allergic asthma: a critical role for pro-inflammatory immune regulation. Pediatr Allergy Immunol. 2018. 29(1):34-41. PMID: 29047170.
  5. Gelfand EW, Joetham A, Wang M, Takeda K, Schedel M. Spectrum of T Lymphocyte Activities Regulating Allergic Lung Inflammation. Immunol Rev. 2017. 278(1):63-86. PMID: 28658551
  6. *Quinn K, *Schedel M, Nkrumah-Elie Y, Joetham A, Armstrong M, Cruickshank-Quinn C, Reisdorph R, Gelfand E, Reisdorph Dysregulation of Metabolic Pathways in a Mouse Model of Allergic Asthma. Allergy. 2017. 72(9):1327-1337. *Both authors contributed equally. PMID: 28213886.
  7. Joetham A, Schedel M, O’Connor BP, Kim S, Takeda K, Abbott J, Gelfand EW. Inducible and naturally occurring T regulatory cells enhance lung allergic responses via divergent transcriptional pathways. J Allergy Clin Immunol. 139(4):1331-1342. PMID: 27542981.
  8. *Schedel M, *Jia Y, Michel S, Takeda K, Domenico J, Joetham A, Ning F, Strand M, Han J, Wang M, Lucas JJ, Vogelberg C, Kabesch M, O’Connor BP, Gelfand EW. 1,25D3 prevents CD8+ Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 Nat Commun. 2016. 7:10213. *both authors contributed equally. PMID: 26750596.
  9. *Toncheva AA, *Potaczek DP, *Schedel M, Gersting SW, Michel S, Krajnov N, Gaertner VD, Klingbeil JM, Illig T, Franke A, Winkler C, Hohlfeld JM, Vogelberg C, von Berg A, Bufe A, Heinzmann A, Laub O, Rietschel E, Simma B, Genuneit J, Muntau AC, Kabesch M. Childhood asthma is associated with mutations and gene expression differences of ORMDL genes which can interact. Allergy. 2015. 70(10):1288-99. *All authors contributed equally. PMID: 26011647.
  10. Schedel M, Michel S, Gaertner VD, Toncheva AA, Depner M, Binia A, Schieck M, Rieger MT, Klopp N, von Berg A, Bufe A, Laub O, Rietschel E, Heinzmann A, Simma B, Vogelberg C, Genuneit J, Illig T, Kabesch M. Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3 and changes in Th2 cytokine levels. J Allergy Clin Immunol. 2015. 136(4):893-903. PMID:
  11. Joetham A, Schedel M, Takeda K, Jia Y, Ashino S, Dakharma A, Lluis A, Okamoto M, Gelfand EW. JNK2 regulates the functional plasticity of naturally occurring T regulatory cells and the enhancement of lung allergic responses, J Immunol. 2014. 193(5):2238-47. PMID: 25070841.
  12. Sharma V, Michel S, Gaertner V, Franke A, Vogelberg C, von Berg A, Bufe A, Heinzmann A, Laub O, Rietschel E, Simma B, Frischer T, Genuneit J, Zeilinger S, Illig T, Schedel M, Potaczek DP, Kabesch M. Fine-mapping of IgE associated loci 1q23, 5q31 and 12q13 using 1000 Genomes Project data, Allergy. 2014. 69(8):1077-8. PMID: 24930997.
  13. Casaca VC, Illi S, Klucker E, Ballenberger N, Schedel M, von Mutius E, Kabesch M, Schaub B. STAT6 polymorphisms are associated with modulated neonatal Regulatory T cell and cytokine responses and atopic dermatitis and asthma/obstructive bronchitis at age 3 years, Allergy. 2013. 68(10):1249-58. PMID: 24053457.
  14. Pandey RC, Michel S, Tesse R, Binia A, Schedel M, Liang L, Klopp N, Franke A, von Berg A, Bufe A, Rietschel E, Heinzmann A, Laub O, Simma B, Frischer T, Genuneit J, Illig T, Kabesch M. Genetic variation in the TLR signaling pathway is associated with childhood asthma, J Allergy Clin Immunol. 2013. 131(2):602-5. PMID: 23273951.
  15. Joetham A, Ohnishi H, Okamoto M, Takeda K, Schedel M, Domenico J, Dakhama A, Gelfand EW. Loss of T regulatory cell suppression following signaling through the GITR is dependent on c-Jun N-terminal kinase activation. J Biol Chem. 2012. 297(21):17100-8. PMID: 22461627.
  16. *Lluis A, *Schedel M, Liu J, Illi S, Depner M, von Mutius E, Kabesch M, Schaub B. Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion. J Allergy Clin Immunol. 2011. 127(6):1587-94. *Both authors contributed equally. PMID: 21546069.
  17. Joetham A, Okamoto M, Takeda K, Schedel M, Ohnishi H, Dakhama A, Gelfand EW. CD8 regulates T regulatory cell production of IL-6 and maintains their suppressive phenotype in allergic lung disease. J Immunol. 2011. 186(1):113-20. PMID: 21115736.
  18. Michel S, Liang L, Depner M, Klopp N, Ruether A, Kumar A, Schedel M, Vogelberg C, von Mutius E, von Berg A, Bufe A, Rietschel E, Heinzmann A, Laub O, Simma B, Frischer T, Genuneit J, Gut IG, Schreiber S, Lathrop M, Illig T, Kabesch M. Unifying candidate gene and GWAS Approaches in Asthma. PLoS One. 2010. 5(11). PMID: 21103062.
  19. Schedel M, Frei R, Bieli C, Cameron L, Adamski J, Lauener R, Kabesch M. An IgE associated polymorphisms in STAT6 alters NF-κB binding, STAT6 promoter activity, and mRNA expression. J Allergy Clin Immunol. 2009. 124(3):583-9. PMID: 19665768.
  20. Suttner K, Rosenstiel P, Depner M, Schedel M, Pinto LA, Ruether A, Adamski J, Klopp N, Illig T, Vogelberg C, Schreiber S, von Mutius E, Kabesch M. TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants. J Allergy Clin Immunol. 2009.123(5):1062-8. PMID: 19362357.
  21. Schedel M, Kabesch M. Genetic variations in cytokines, asthma and atopy: The role of IL-4/IL-13 pathway polymorphisms. Book chapter in Allergy Frontiers: Epigenetics to future perspectives, Springer publisher. 2009. 401-419.
  22. Suttner K, Ruoss I, Rosenstiel P, Depner M, Pinto LA, Schedel M, Adamski J, Illig T, Schreiber S, von Mutius E, Kabesch M. 2009. HLX1 gene variants influence the development of childhood asthma. J Allergy Clin Immunol. 2008. 123(1):82-88. PMID: 19038437.
  23. *Schedel M, *Pinto LA, Schaub B, Rosenstiel P, Cherkasov D, Cameron L, Klopp N, Illig T, Vogelberg C, Weiland SK, von Mutius E, *Lohoff M, *Kabesch M. IRF1 gene variations influence IgE regulation and atopy. Am J Respir Crit Care Med. 2008. 177(6):613-21, *both authors contributed equally. PMID:
  24. Schedel M, Depner M, Schoen C, Weiland SK, Vogelberg C, Niggemann B, Lau S, Fritzsch C, Illig T, Klopp N, Wahn U, von Mutius E, Nickel R, Kabesch M. The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations. Respir Res. 2006. 19;7:91. PMID: 16784537.
  25. Kabesch M, Schedel M, Carr D, Woitsch B, Fritzsch C, Weiland SK, von Mutius E. Interleukin 4/ Interleukin 13 pathway genetics strongly influence the serum IgE levels and childhood asthma. J Allergy Clin Immunol. 2006. 117(2):269-74. PMID: 16461126.
  26. Hysi P, Kabesch M, Moffatt MF, Schedel M, Carr D, Zhang Y, Boardman B, von Mutius E, Weiland SK, Leupold W, Fritzsch C, Klopp N, Musk AW, James A, Nunez G, Inohara N, Cookson WO. NOD1 variation, immunoglobulin E and asthma. Hum Mol Genet. 2005. 1;14 (7):935-41. PMID: 15718249.
  27. Weidinger S, Klopp N, Wagenpfeil S, Rummler L, Schedel M, Kabesch M, Schafer T, Darsow U, Jakob T, Behrendt H, Wichmann HE, Ring J, Illig T. Association of a STAT6 haplotype with elevated serum IgE levels in a population-based cohort of white adults. J Med Genet. 2004. 41(9):658-63. PMID:
  28. Schedel M, Carr D, Woitsch B, Stachel D, Schmid I, Fritzsch C, Weiland SK, von Mutius E, Kabesch M. A signal transducer and activator of transcription 6 haplotype influences the regulation of serum IgE levels. J Allergy Clin Immunol. 2004. 114:1100-5. PMID: 15536416.